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KMID : 0984720060380050266
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Infection and Chemotherapy
2006 Volume.38 No. 5 p.266 ~ p.270
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Tuberculous Lymphadenitis in Patients with Myelogenous Leukemia
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Lee Chang-Seop
Oh Myoung-Don
Choe Kang-Won
Song Jin-Soo
Choe Pyeong-Gyun
Cho Jae-Hyun
Bang Ji-Hwan
Park Kyung-Hwa
Park Wan-Beom
Kim Hong-Bin
Kim Nam-Joong
Yoon Sung-Soo
Park Seon-yang
Kim Byoung-Kook
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Abstract
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During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and,
fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections.
Mycobacterium tuberculosis infection was reported very rarely in these patients. This report
describes four patients with M. tuberculosis infection identified from 185 adult patients who were
diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient
with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia
patients. Sites of infection were all lymph nodes. Three among four patients were presented with
lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy
after induction chemotherapy. There was no patient presented with lymphadenopathy during the
neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous
leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase.
An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph
node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia
patient with lymphadenopathy, especially in the countries in which the disease is endemic.
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KEYWORD
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Mycobacterium tuberculosis, Acute myelogenous leukemia, Lymphadenopathy
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